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Depression is more than simply feeling unhappy or fed up for a few days.

Most people go through periods of feeling down, but when you're depressed you feel persistently sad for weeks or months, rather than just a few days.

Some people think depression is trivial and not a genuine health condition. They're wrong – it is a real illness with real symptoms. Depression is not a sign of weakness or something you can "snap out of" by "pulling yourself together".


Depression affects people in different ways and can cause a wide variety of symptoms.

They range from lasting feelings of unhappiness and hopelessness, to losing interest in the things you used to enjoy and feeling very tearful. Many people with depression also have symptoms of anxiety.

There can be physical symptoms too, such as feeling constantly tired, sleeping badly, having no appetite or sex drive, and various aches and pains.

Source: NHS

Research Summary
Research summary
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Depresion trials open globally

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Depresion trials open in the UK

17, 699

Participants required for UK studies

Global trials - phase

Phase indicates how far along the treatment is in the development process. Phase 1 indicates very early, phase 4 is later.

Global trials - interventions

Intervention is the type of treatment that will be being tested during the trial.

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Diabetes type 2 spotlights
Nye Spotlight Trials
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Study type: interventional


1500 estimated participants


Recruitment ends 2027-02-04


At Novo Nordisk Investigational Site & 177 more locations


Male or female, age greater than or equal to 18 years at the time of signing informed consent

Diagnosed with type 2 diabetes mellitus. HbA1c of 7.0-10.0% (53-86 mmol/mol) (both inclusive).

Eye inclusion criteria (both eyes must meet all criteria):

  • Early Treatment Diabetic Retinopathy Study (ETDRS) level of 10-75 (both inclusive) evaluated by fundus photography and confirmed by central reading centre

  • No ocular or intraocular treatment for diabetic...

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