Depression
Overview
Depression is more than simply feeling unhappy or fed up for a few days.
Most people go through periods of feeling down, but when you're depressed you feel persistently sad for weeks or months, rather than just a few days.
Some people think depression is trivial and not a genuine health condition. They're wrong – it is a real illness with real symptoms. Depression is not a sign of weakness or something you can "snap out of" by "pulling yourself together".
Symptoms
Depression affects people in different ways and can cause a wide variety of symptoms.
They range from lasting feelings of unhappiness and hopelessness, to losing interest in the things you used to enjoy and feeling very tearful. Many people with depression also have symptoms of anxiety.
There can be physical symptoms too, such as feeling constantly tired, sleeping badly, having no appetite or sex drive, and various aches and pains.
Source: NHS
Research Summary
1,254
Depression trials open globally
51
Depression trials open in the UK
17, 699
Participants required for UK studies
Global trials - phase
Phase indicates how far along the treatment is in the development process. Phase 1 indicates very early, phase 4 is later.
Global trials - interventions
Intervention is the type of treatment that will be being tested during the trial.
Nye Spotlight Trials
Psilocybin in Depression Resistant to Standard Treatments
Study type: interventional
60 estimated participants
Recruitment ends 2023-11-01
Clinical Research Facility, King's College Hospital, London
About this study
A single centre clinical trial to evaluate the feasibility, safety and efficacy of psilocybin, given under supportive conditions, in a randomised...
Eligibility
Inclusion Criteria:
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Age 25 - 80 years
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Fluent in the English language
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Fulfil Diagnostic and Statistical Manual of Mental...
Alpha-Stim AID and Major Depressive Disorder
Study type: interventional
230 estimated participants
Recruitment ends 2022-12-31
University of Nottingham, Nottingham
About this study
The study will be a multi-centre parallel group, double blind, non-commercial, randomised controlled superiority trial. Study participants will be referred from...
Eligibility
Inclusion Criteria:
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Aged 16 years and above. There is no maximum age limit.
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Diagnosis of current Major Depressive Episode...
Neural Mechanisms With CES in Depression
Study type: interventional
60 estimated participants
Recruitment ends 2023-12-31
Oxford Brooke University, Oxford
About this study
This study will examine the effect of cranial electrotherapy stimulation (CES) treatment on adults with depression. Scalp based electroenc...
Eligibility
Inclusion Criteria:
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Male or female subjects, 18 to 65 years of age.
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Each subject must have a level of understanding sufficient to agree to all required tests and examinations and sign an informed consent document....
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
Study type: observational
500 estimated participants
Recruitment ends 2025-12-01
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Glenfield hospital, Leicester
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King's College London, London
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Wolfson Research Centre, Newcastle
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Mendip HTT / St Andrew's Ward, Wells
About this study
The primary objective of this study is to assess short, mid and long-term clinical outcomes in patients with difficult to treat depression (such as patients...
Eligibility
Be at least 18 years of age.
Have a documented primary diagnosis of chronic (>2 years) or recurrent (2 or more prior episodes) major depressive episode that has not adequately responded to an adequate number of antidepressant treatments, as per local...
Antidepressant Trial With P2X7 Antagonist JNJ-54175446
Study type: interventional
142 estimated participants
Recruitment ends 2022-06-30
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Addenbroooke's Hospital, Cambridge
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Cardiff University, Cardiff
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Queen Elizabeth University Hospital, Glasgow
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The Maurice Wohl Clinical Neuroscience Institute, London
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Warneford Hospital, Oxford
About this study
Depression is one of the most important causes of disability in the world today, with major personal, social and economic costs. Although some moderately...
Eligibility
Inclusion Criteria:
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Provided written informed consent
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Between the age of 18 to 60 years inclusive
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Meets the Diagnostic and statistical manual - 5 (DSM-5) diagnostic criteria for MDD without psychotic...